Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Sleepiness, depression, personality changes, erratic behavior, psychosis, extreme fatigue, and all kinds of other symptoms can happen from excessive ammonia if not cleared out of the body, especially from the blood brain barrier. Milk thistle (Silybum marianum) is an herbal remedy that has long been used in Iran. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Milk thistle is generally considered safe when taken by mouth (1, 45). One study has shown that milk thistle seed extract has estrogenic effects and effects on memory by estrogen. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. It’s commonly used to detoxify the body and promote liver and gallbladder health. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Milk thistle as a beauty product When applied topically, milk thistle can reduce inflammation and improve skin conditions. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Milk thistle may reduce anxiety and improve depression. As Little Bear said, milk thistle can cause a reaction in those with a rag weed allergy - like me. Taking milk thistle with this hepatitis C medication might increase levels of the drug in your blood plasma. In 2010, a double-blind, placebo-controlled study compared the effects of milk thistle to the antidepressant Prozac (fluoxetine) in treating OCD (600 milligrams of milk thistle vs 30 milligrams of Prozac daily). The authors of this study note that silybin shows promise in memory impairment diseases.3 Depression and anxiety are associated with increased risk of developing AD. Also, as they said, it's use is for protecting and detoxing the liver. As a woman prepares to end her childbearing years, hormonal changes take place. Milk Thistle seeds contain the highest concentrations of the active compound, silymarin. Simeprevir. Milk thistle is a herbal drug that has been used for thousands of years to treat many different health problems. Other uses not proven with research have included treating malaria , mushroom poisoning , spleen or gallbladder problems, menstrual problems, liver problems (such as … Some even claim that milk thistle is effective in treating depression and anxiety, but there’s not enough research to support these claims. 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